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Editorial Transparency

Change Log

A transparent record of every factual correction, technical fix, legal update, and content improvement made to this site. TryTrutide is an accuracy-first platform — when we get something wrong or the evidence changes, we correct it publicly and explain why.

AccuracyTechnicalLegalUX / AccessibilitySEO / Schema
v2.3

Physician-Supervised Injectable Weight-Loss Program launched — /start-program

  • ▸New page /start-program: 6-step clinical intake form for the physician-supervised injectable weight-loss program ($477 / 2 months).
  • ▸Step 1: Eligibility screening — 6 yes/no questions with automatic disqualification routing.
  • ▸Step 2: Identity & contact — full name, DOB, state, mobile phone, email with confirmation.
  • ▸Step 3: Shipping & billing address — with "same as shipping" toggle for billing.
  • ▸Step 4: Payment authorization — patient authorizes $477 one-time charge (processed by Doctor Staffers only after physician approval; no card capture on this form).
  • ▸Step 5: Medical history — height/weight/BMI calculator, blood pressure, medications, allergies, conditions, prior weight-management medications, safety screening questions with detail fields.
  • ▸Step 6: Review & submit — summary table, electronic signature, certification checkbox.
  • ▸Disqualified screen: routes ineligible patients to consult their primary care physician.
  • ▸Confirmation screen: displays confirmation number and payment/next-step notice.
  • ▸POST /api/clinical-intake: server-side validation, honeypot spam filter, structured HTML + plain-text email to PHYSICIAN_REVIEW_EMAIL, Reply-To = patient email.
  • ▸Homepage program section added: headline, price, includes list, How It Works (3 steps), FAQ (6 items), badges, CTA linking to /start-program.
  • ▸/start-program added to sitemap with priority 0.85.
  • ▸WebPage + BreadcrumbList JSON-LD schema on /start-program.
Accuracy

Regulatory status language corrected to reflect Lilly's announced Q1 2027 BLA submission plan

  • ▸Homepage hero metaLine updated: "FDA Decision Pending" replaced with "Regulatory Submission Planned Q1 2027" — the prior phrasing incorrectly implied an application was already under FDA review.
  • ▸What Is Retatrutide timeline entry corrected: "FDA review ongoing" replaced with "Phase 3 development / pre-submission — no FDA approval as of September 2026."
  • ▸As of September 2026, retatrutide remains investigational. Eli Lilly has publicly announced a plan to submit a Biologics License Application (BLA) in Q1 2027. No application has been accepted for review and no PDUFA target date currently exists.
  • ▸BLA terminology used consistently throughout to reflect Lilly's announced U.S. filing plan.
v2.2
SEO / Schema

FAQ expanded to ~50 questions; answer-first blocks added to key pages; sitemap cleanup

  • ▸FAQ page expanded from ~22 to ~50 questions across 7 categories: Basics, Mechanism, Clinical Trials, Safety, Regulatory Status, Comparisons, and Sources.
  • ▸New FAQ categories cover: all TRIUMPH/TRANSCEND trials by name and NCT number, GIP/glucagon mechanism deep-dives, single/dual/triple agonist distinctions, liver fat data, NDA definition, FDA decision timeline, NEJM/PubMed publication status, topline vs. peer-reviewed distinction, and all populations studied.
  • ▸JSON-LD FAQPage mainEntity updated with 30 structured Q&A pairs for AEO/AI search visibility.
  • ▸"Direct Answer" box added to /what-is-retatrutide and /how-it-works — 40–80 word AEO-optimized summary at top of each page.
  • ▸Key Facts block on /what-is-retatrutide updated with development name (LY3437943), Phase 3 program detail, Phase 3 topline weight loss (28.3%), planned Q1 2027 submission, and lastVerified date.
  • ▸Key Facts block added to /how-it-works (was missing entirely): mechanism, administration, dose escalation, Phase 3 doses, Phase 2 and Phase 3 peak weight loss, lastVerified.
  • ▸Research Sources page (/retatrutide-research-sources) schema fix: secondaryHref/secondaryLabel made optional in content schema to allow peer-reviewed cards without secondary links.
  • ▸/fda, /reddit, and /search removed from XML sitemap (redirect stubs — not indexable).
  • ▸lastmod dates updated to 2026-09-17 for /faq, /what-is-retatrutide, /how-it-works, /retatrutide-research-sources, /source-library, /change-log.
  • ▸NCT05929547 (incorrect TRIUMPH-2 identifier) fully purged from codebase; replaced with correct NCT05929066 everywhere including schema.ts comment.
Accuracy

Source Library expanded with 9 new primary sources

  • ▸Added Nature Medicine (2024): Phase 2a liver fat substudy (MASLD/MAFLD outcomes).
  • ▸Added Cell Discovery / Nature Portfolio (2024): structural biology of retatrutide receptor binding.
  • ▸Added International Journal of Obesity (2024): pipeline review of next-generation GLP-1 receptor agonists.
  • ▸Added PubMed Phase 1b T2D study (Hartman et al., 2022, PMID 36354040).
  • ▸Added Eli Lilly pipeline page (lilly.com/science/research-development/pipeline).
  • ▸Added Eli Lilly TRIUMPH-1 investor announcement (May 21, 2026).
  • ▸Added Eli Lilly TRIUMPH-2/3 investor announcement (July 23, 2026).
  • ▸Added Wikipedia retatrutide article (labeled as general reference / secondary source).
  • ▸Source Library lastReviewed date updated to September 17, 2026.
v2.1
Accuracy

Added TRIUMPH-2 dose-level figures to results data table

  • ▸TRIUMPH-2 table entry now shows efficacy-estimand results: 4 mg −12.7%, 9 mg −19.1%, 12 mg −20.8% vs. placebo −4.0% at 80 weeks.
  • ▸A1C reduction (average 1.6 percentage points) added to TRIUMPH-2 notes.
  • ▸TRIUMPH-3 population corrected to include "with or without type 2 diabetes."
  • ▸TRIUMPH-3 notes updated to clarify that topline data do not establish cardiovascular-outcome benefit.
SEO / Schema

Removed /fda, /reddit, /search from XML sitemap; fixed Privacy/Terms canonicals

  • ▸/fda is a 301 redirect to /fda-regulation — excluded from sitemap per spec.
  • ▸/reddit is a 301 redirect to /reddit-observatory — excluded from sitemap per spec.
  • ▸/search is noindex,follow — excluded from sitemap per spec.
  • ▸Privacy and Terms pages now use hardcoded absolute HTTPS canonicals.
  • ▸Added WebPage and BreadcrumbList JSON-LD schema to Privacy and Terms pages.
  • ▸Added Open Graph and Twitter meta tags to Privacy and Terms pages.
SEO / Schema

Metadata cleanup — 9 priority pages shortened to 50–65 char titles

  • ▸what-is-retatrutide: title 72→65 chars; description 196→162 chars.
  • ▸research-grade-retatrutide: title 72→66 chars; description 163→152 chars.
  • ▸retatrutide-vs-next-generation-obesity-drugs: title 87→60 chars; description 175→162 chars.
  • ▸fake-illicit-retatrutide: title 88→72 chars.
  • ▸weight-loss-support: description 176→158 chars.
  • ▸clinical-trials: title 72→60 chars; description updated to reflect TRIUMPH-1/2/3 topline status.
  • ▸combinations: title 79→68 chars.
Accuracy

Published 8 new original articles

  • ▸/retatrutide-gold-rush — Investigation: inside the market for an unapproved drug.
  • ▸/retatrutide-powder-vials-reconstitution — Why "reconstitution required" is a warning signal.
  • ▸/bacteriostatic-water-shortage-retatrutide — Limited supply vs. confirmed FDA shortage; Rx-only status.
  • ▸/amazon-syringes-prescription-peptide-use — Amazon has not banned all syringes; availability depends on classification and state law.
  • ▸/triumph-2-retatrutide-results — Dose-level results, A1C findings, and evidence status.
  • ▸/triumph-3-retatrutide-results — Weight loss and cardiovascular findings explained.
  • ▸/counterfeit-retatrutide-semaglutide-warning — TGA safety alert (September 14, 2026).
  • ▸/ohio-retatrutide-clinic-enforcement — Enforcement analysis: Ohio clinic actions.
  • ▸All 8 articles include Article/NewsArticle schema, BreadcrumbList schema, AJ Pakpour attribution, published/modified dates, evidence status statements, and 3–6 authoritative citations.
SEO / Schema

Updated internal linking and hub pages for new articles

  • ▸TRIUMPH-2 and TRIUMPH-3 articles added to results.tsx RelatedReading.
  • ▸Counterfeit warning and Gold Rush articles added to fake-illicit-retatrutide.tsx RelatedReading.
  • ▸Gold Rush and Ohio enforcement articles added to online-retatrutide-peptide-sellers.tsx RelatedReading.
  • ▸All 8 articles added to guides.tsx with new Investigations and Evidence categories.
  • ▸All 8 articles added to seo-routes.ts with priority 0.8–0.9 and lastmod 2026-09-16.
Accuracy

TRIUMPH Phase 3 results and Lilly 5-study status updated sitewide

  • ▸Added TRIUMPH-2 topline results (up to 20.8% weight loss at 80 weeks, announced July 23, 2026) across all relevant pages.
  • ▸Added TRIUMPH-3 topline results (up to 22.6% weight loss at 80 weeks, announced July 23, 2026) across all relevant pages.
  • ▸Updated Eli Lilly status to reflect five positive Phase 3 studies and stated intent to support global submissions for obesity, knee osteoarthritis pain, and obstructive sleep apnea.
  • ▸Corrected news.tsx status panel: TRIUMPH-1/2/3 topline reported; TRIUMPH-CVOT ongoing.
  • ▸Corrected results.tsx Phase 3 status label to reflect TRIUMPH-1/2/3 topline completion.
  • ▸Corrected news.tsx FAQ answers that incorrectly stated TRIUMPH-2 was still ongoing after July 23, 2026 topline announcement.
  • ▸Confirmed canonical efficacy figures: 28.3% (12 mg), 25.9% (9 mg), 19.0% (4 mg) at 80 weeks; 30.3% extension at 104 weeks.
  • ▸TRIUMPH-1 24.2%/48wks correctly labeled as Phase 2 throughout.
Accuracy

Removed all boxed-warning language applied to retatrutide

  • ▸Retatrutide is investigational and has no FDA-approved prescribing label; it cannot carry a "boxed warning."
  • ▸Corrected faq.tsx JSON-LD answer: replaced "carries a precautionary boxed warning" with accurate class-level MTC/MEN2 precaution language.
  • ▸Corrected retatrutide-vs-semaglutide.tsx comparison table: retatrutide now reads "Class-level MTC/MEN2 precaution (investigational; no approved label)" vs. semaglutide's accurate "FDA boxed warning."
  • ▸Corrected guides.tsx card description: "MTC/MEN2 boxed warning" replaced with "MTC/MEN2 precautions."
  • ▸Glossary MTC entry retained accurate language: "GLP-1 receptor agonists carry a boxed warning" (true for approved drugs in the class).
Accuracy

Corrected 503A/503B legal explanations

  • ▸Clarified that 503A pharmacies compound for individual patients with a valid prescription; they do not compound retatrutide for office stock or general sale.
  • ▸Clarified that 503B outsourcing facilities may produce larger batches but are subject to FDA registration, cGMP, and cannot compound copies of commercially available drugs.
  • ▸Removed any language suggesting either pathway is a legal route to obtain retatrutide outside of clinical trials.
Accuracy

Added September 14, 2026 TGA safety alert

  • ▸Added TGA (Australian Therapeutic Goods Administration) safety alert to news.tsx: product sold as retatrutide contained no retatrutide; contained undeclared semaglutide at approximately 8× normal level.
  • ▸Consumer experienced uncontrollable vomiting and a torn esophagus requiring hospital treatment.
  • ▸Alert correctly scoped to Australian TGA investigation; noted U.S. FDA has not issued a parallel alert.
  • ▸Cross-referenced from fake-illicit-retatrutide.tsx and online-retatrutide-peptide-sellers.tsx.
SEO / Schema

Fixed duplicate canonical tags and duplicate schema

  • ▸Removed canonical tag from RootLayout.tsx — it was emitting a generic "/" canonical on every page, overriding per-page canonicals.
  • ▸Removed Organization and WebSite schema from RootLayout.tsx — these were duplicating the per-page @graph blocks.
  • ▸RootLayout now emits only the site-wide default title and meta description as fallbacks.
  • ▸Per-page Helmet blocks are now the sole source of canonical, OG, and JSON-LD on every route.
  • ▸Eliminated duplicate BreadcrumbList schema that was being emitted by both the Breadcrumb component and page-level JSON-LD on some pages.
SEO / Schema

Fixed AJ Pakpour ProfilePage schema

  • ▸Corrected @type to "ProfilePage" with a nested "mainEntity" Person node.
  • ▸sameAs array contains only ["https://ajpakpour.com"] — no unverified social profiles.
  • ▸Removed any medicalReviewer, reviewedBy, or MedicalWebPage schema sitewide.
  • ▸Role consistently stated as "Founder & Publisher, TryTrutide" across sitemap, explore, and search pages.
SEO / Schema

Improved titles and meta descriptions; fixed /research breadcrumb and indexing

  • ▸Audited all page titles: target 50–65 characters, include brand name, descriptive keyword.
  • ▸Audited all meta descriptions: target 145–165 characters, include primary keyword and value proposition.
  • ▸Added breadcrumb component to /research index page.
  • ▸/search page confirmed noindex,follow — correct for a dynamic search UI.
  • ▸/sitemap page confirmed noindex,follow — correct for a UI sitemap.
  • ▸Server-side 301 redirects confirmed: /fda → /fda-regulation, /reddit → /reddit-observatory.
UX / Accessibility

Fixed physician questionnaire accessibility and form semantics

  • ▸All form inputs now have associated <label> elements with matching htmlFor/id pairs.
  • ▸Error messages use role="alert" for screen reader announcement.
  • ▸Yes/No safety question buttons use aria-pressed for state communication.
  • ▸Step navigation buttons meet 44px minimum touch target height.
  • ▸Duplicate-submission guard prevents double-posting on slow connections.
  • ▸Honeypot field added for spam filtering.
Legal

Rewrote privacy policy to match actual site practices

  • ▸Privacy policy now accurately describes data collected: physician review form submissions, contact form submissions, and standard server logs.
  • ▸Removed references to data practices not in use (advertising pixels, third-party data brokers).
  • ▸Added explicit section on physician review form data handling and recipient (rx@connectscripts.com).
  • ▸Updated /privacy and /terms metadata: OG tags, schema (WebPage), and breadcrumbs.
Technical

Fixed HEAD request returning 404; replaced broken external links

  • ▸Added HEAD handler in src/server/entry.ts: HEAD requests for valid public pages now return 200 with correct headers instead of 404.
  • ▸Audited all external links sitewide; replaced confirmed broken URLs with current equivalents or removed them.
  • ▸ClinicalTrials.gov search links updated to current URL format.
  • ▸FDA Drugs@FDA link verified active.
UX / Accessibility

Mobile/responsive QA pass

  • ▸Homepage status panel: converted from fragile flex-with-manual-borders to auto-fit grid; border logic no longer breaks on single-column mobile.
  • ▸Research article cards, framework quadrants, and directory hub cards: removed hardcoded borderRight logic that assumed a fixed column count; replaced with uniform borderBottom.
  • ▸Hero section padding: converted to clamp() for graceful scaling from 375px up.
  • ▸Hero text container: added width: 100% to prevent overflow on narrow viewports.
  • ▸Footer brand column: removed minWidth: 180px override that could fight the auto-fit grid.
  • ▸Global CSS: added @media (max-width: 360px) rule tightening horizontal padding to 1rem on very small screens.
SEO / Schema

Updated dateModified to 2026-09-16 on all changed pages

  • ▸All pages modified during this correction pass have dateModified set to 2026-09-16 in their WebPage JSON-LD.
  • ▸reddit-observatory.tsx dateModified corrected from 2026-09-13 to 2026-09-16.

This change log covers substantive editorial, factual, legal, and technical changes. Minor copy edits, formatting adjustments, and routine link maintenance are not individually logged. For questions about a specific correction, contact .contact@trytrutide.com. See also the Medical Disclaimer and Privacy Policy.